interleukin 4 การใช้

• Th2 also produce Interleukin 4, which facilitates B cell isotype switching.
• For instance, a pair of redundant cytokines are interleukin 4 and interleukin 13.
• Lupeol to decreases IL-4 ( interleukin 4 ) production by T-helper type 2 cells.
• Among T cells, the encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells.
• Th2 immune responses result in the release of cytokines associated with inflammation reduction such as interleukin 4, interleukin 5 and interleukin 10.
• Interleukin 4 ( IL4 ) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine.
• CD1d-presented lipid antigens activate a special class of T cells, known as Th1 and Th2 cytokines, typically represented by interferon-gamma and interleukin 4 production.
• The gene that is mutated in some asthma victims contains the building instructions for a docking spot, or receptor, for the chemical called interleukin 4.
• Fisher used Interleukin 4 ( IL4 ) genes as a model for investigating the activities involved in acquisition and heritable maintenance of a decondensed chromatin assembly.
• This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the STAT-dependent Interleukin 4 ( IL-4 ) responses of B cells.
• TAAR1 agonists ( specifically, trace amines ) have also been shown to induce interleukin 4 secretion in T-cells and immunoglobulin E ( IgE ) secretion in B cells.
• TAMs have been induced in vitro by exposing macrophage progenitors to different immune regulatory cytokines, such as interleukin 4 ( IL-4 ) and interleukin 13 ( IL-13 ).
• Ron Jackson of CSIRO's wildlife division and Ian Ramshaw at the Australian National University, both in Canberra, inserted into a mousepox virus a gene that creates large amounts of interleukin 4.
• This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells.
• The work suggests eosinophils ( a type of white blood cell ) in fat tissue play an important role in preventing insulin resistance by secreting interleukin 4, which in turn switches macrophages into " alternative activation ".
• Human and animal studies have provided evidence of decreased Th1 and Th17 immune responses with a shift to Th2 cytokine production resulting in significantly decreased levels of interleukin 12 and IFNy with simultaneous increases in the regulatory T cells, interleukin 4, interleukin 5 and interleukin 10 of test subjects.
• It dilates airways ( bronchodilation ) contracted by the allergic mediator, histamine; inhibits Immunoglobulin E-activated mast cells from releasing histamine and leukotrienes ( viz ., LTC4, LTD4, and LTE4 ), all of which have bronchoconstricting and otherwise pro-allergic actions; inhibits pro-allergic eosinophil apoptosis, chemotaxis, and release of pro-allergic granule contents; and reduces release of the pro-allergic cytokines Interleukin 5, Interleukin 4, and interleukin 13 from human blood mononuclear cells.